SAB: DNA-up: DNA-Origami goes Waferlevel

Nanotechnologies, as the key to miniaturization and thus increased functional density, face many challenges. Top-down structuring by means of lithographic processes (layer deposition, masking, etching) is physically limited by the radiation sources used or is simply not economical for small structure sizes <10nm. Bottom-up methods, i.e. structure generation by means of physical, chemical or molecular effects, offer a possible connection technology for this. The DNA origami method uses the natural, intrinsic programmability of DNA to build up variously shaped 2D and 3D nanostructures by means of self-organization. A long cyclic DNA strand is folded using many short DNA fragments ("staples"). Each DNA clamp is precisely defined in its position and unique in its DNA sequence. If these short DNA strands are now extended, overhangs are created to which functional nanoelements (nanoparticles, molecules, antibodies, ...) can be attached. Since each DNA clamp is unique and its position is determined, nanoelements can be positioned on the DNA origami with a resolution of individual nucleic acids (approx. 2.5 - 5 nm) by cleverly designing the clamps. In addition, different nanoelements can be combined and positioned in relation to each other. This results in complex, heterogeneous nanosystems through self-assembly.

Diese Maßnahme wird aus Mitteln der Europäischen Union unterstützt und mitfinanziert durch Steuermitteln auf der Grundlage des vom Sächsischen Landtag beschlossenen Haushaltes.